Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity
Identifieur interne : 001330 ( Main/Exploration ); précédent : 001329; suivant : 001331Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity
Auteurs : Chan-Ki Min ; Shinhye Cheon [Corée du Sud] ; Na-Young Ha ; Kyung Mok Sohn [Corée du Sud] ; Yuri Kim ; Abdimadiyeva Aigerim ; Hyun Mu Shin ; Ji-Yeob Choi ; Kyung-Soo Inn ; Jin-Hwan Kim [Corée du Sud] ; Jae Young Moon [Corée du Sud] ; Myung-Sik Choi ; Nam-Hyuk Cho ; Yeon-Sook Kim [Corée du Sud]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Charge virale, Cinétique, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Cytokines (métabolisme), Excrétion virale, Facteur de croissance épidermique (métabolisme), Femelle, Humains, Hyperleucocytose (mortalité), Hyperleucocytose (étiologie), Indice de gravité médicale, Infections à coronavirus (), Infections à coronavirus (immunologie), Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Lymphopénie (mortalité), Lymphopénie (étiologie), Mâle, Pneumopathie infectieuse (mortalité), Pneumopathie infectieuse (étiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Thrombopénie (mortalité), Thrombopénie (étiologie).
- MESH :
- immunologie : Infections à coronavirus.
- mortalité : Hyperleucocytose, Infections à coronavirus, Lymphopénie, Pneumopathie infectieuse, Thrombopénie.
- métabolisme : Cytokines, Facteur de croissance épidermique.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus.
- étiologie : Hyperleucocytose, Lymphopénie, Pneumopathie infectieuse, Thrombopénie.
- Adulte, Adulte d'âge moyen, Charge virale, Cinétique, Excrétion virale, Femelle, Humains, Indice de gravité médicale, Infections à coronavirus, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Coronavirus Infections (complications), Coronavirus Infections (immunology), Coronavirus Infections (mortality), Coronavirus Infections (virology), Cytokines (metabolism), Epidermal Growth Factor (metabolism), Female, Humans, Kinetics, Leukocytosis (etiology), Leukocytosis (mortality), Lymphopenia (etiology), Lymphopenia (mortality), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (physiology), Pneumonia (etiology), Pneumonia (mortality), Severity of Illness Index, Thrombocytopenia (etiology), Thrombocytopenia (mortality), Viral Load, Virus Shedding.
- MESH :
- chemical , metabolism : Cytokines, Epidermal Growth Factor.
- complications : Coronavirus Infections.
- etiology : Leukocytosis, Lymphopenia, Pneumonia, Thrombocytopenia.
- immunology : Coronavirus Infections.
- mortality : Coronavirus Infections, Leukocytosis, Lymphopenia, Pneumonia, Thrombocytopenia.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Adult, Aged, Aged, 80 and over, Female, Humans, Kinetics, Male, Middle Aged, Severity of Illness Index, Viral Load, Virus Shedding.
Abstract
Despite the ongoing spread of MERS, there is limited knowledge of the factors affecting its severity and outcomes. We analyzed clinical data and specimens from fourteen MERS patients treated in a hospital who collectively represent a wide spectrum of disease severity, ranging from mild febrile illness to fatal pneumonia, and classified the patients into four groups based on severity and mortality. Comparative and kinetic analyses revealed that high viral loads, weak antibody responses, and lymphopenia accompanying thrombocytopenia were associated with disease mortality, whereas persistent and gradual increases in lymphocyte responses might be required for effective immunity against MERS-CoV infection. Leukocytosis, primarily due to increased neutrophils and monocytes, was generally observed in more severe and fatal cases. The blood levels of cytokines such as IL-10, IL-15, TGF-β, and EGF were either positively or negatively correlated with disease mortality. Robust induction of various chemokines with differential kinetics was more prominent in patients that recovered from pneumonia than in patients with mild febrile illness or deceased patients. The correlation of the virological and immunological responses with disease severity and mortality, as well as their responses to current antiviral therapy, may have prognostic significance during the early phase of MERS.
The online version of this article (doi:10.1038/srep25359) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/srep25359
PubMed: 27146253
PubMed Central: 4857172
Affiliations:
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5905</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Cheon, Shinhye" sort="Cheon, Shinhye" uniqKey="Cheon S" first="Shinhye" last="Cheon">Shinhye Cheon</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.254230.2</institution-id><institution-id institution-id-type="ISNI">0000 0001 0722 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institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Sohn, Kyung Mok" sort="Sohn, Kyung Mok" uniqKey="Sohn K" first="Kyung Mok" last="Sohn">Kyung Mok Sohn</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.254230.2</institution-id><institution-id institution-id-type="ISNI">0000 0001 0722 6377</institution-id><institution>Division of Infectious Diseases, Department of Internal Medicine,</institution><institution>Chungnam National University School of Medicine,</institution></institution-wrap>Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Daejeon</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Shin, Hyun Mu" sort="Shin, Hyun Mu" uniqKey="Shin H" first="Hyun Mu" last="Shin">Hyun Mu Shin</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Cancer Research Institute, Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.289247.2</institution-id><institution-id institution-id-type="ISNI">0000 0001 2171 7818</institution-id><institution>Department of Pharmaceutical Science,</institution><institution>College of Pharmacy, Kyung Hee University,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Kim, Jin Hwan" sort="Kim, Jin Hwan" uniqKey="Kim J" first="Jin-Hwan" last="Kim">Jin-Hwan Kim</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.254230.2</institution-id><institution-id institution-id-type="ISNI">0000 0001 0722 6377</institution-id><institution>Department of Radiology,</institution><institution>Chungnam National University School of Medicine,</institution></institution-wrap>Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Daejeon</wicri:regionArea></affiliation></author><author><name sortKey="Moon, Jae Young" sort="Moon, Jae Young" uniqKey="Moon J" first="Jae Young" last="Moon">Jae Young Moon</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.254230.2</institution-id><institution-id institution-id-type="ISNI">0000 0001 0722 6377</institution-id><institution>Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine,</institution><institution>Chungnam National University School of Medicine,</institution></institution-wrap>Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Daejeon</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Department of Biomedical Sciences,</institution><institution>Seoul National University College of Medicine,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.31501.36</institution-id><institution-id institution-id-type="ISNI">0000 0004 0470 5905</institution-id><institution>Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital,</institution></institution-wrap>Seoul Republic of Korea</nlm:aff></affiliation></author><author><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.254230.2</institution-id><institution-id institution-id-type="ISNI">0000 0001 0722 6377</institution-id><institution>Division of Infectious Diseases, Department of Internal Medicine,</institution><institution>Chungnam National University School of Medicine,</institution></institution-wrap>Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Daejeon</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Cytokines (metabolism)</term><term>Epidermal Growth Factor (metabolism)</term><term>Female</term><term>Humans</term><term>Kinetics</term><term>Leukocytosis (etiology)</term><term>Leukocytosis (mortality)</term><term>Lymphopenia (etiology)</term><term>Lymphopenia (mortality)</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Pneumonia (etiology)</term><term>Pneumonia (mortality)</term><term>Severity of Illness Index</term><term>Thrombocytopenia (etiology)</term><term>Thrombocytopenia (mortality)</term><term>Viral Load</term><term>Virus Shedding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Cinétique</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Cytokines (métabolisme)</term><term>Excrétion virale</term><term>Facteur de croissance épidermique (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Hyperleucocytose (mortalité)</term><term>Hyperleucocytose (étiologie)</term><term>Indice de gravité médicale</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (virologie)</term><term>Lymphopénie (mortalité)</term><term>Lymphopénie (étiologie)</term><term>Mâle</term><term>Pneumopathie infectieuse (mortalité)</term><term>Pneumopathie infectieuse (étiologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Thrombopénie (mortalité)</term><term>Thrombopénie (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Epidermal Growth Factor</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Leukocytosis</term><term>Lymphopenia</term><term>Pneumonia</term><term>Thrombocytopenia</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Leukocytosis</term><term>Lymphopenia</term><term>Pneumonia</term><term>Thrombocytopenia</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Hyperleucocytose</term><term>Infections à coronavirus</term><term>Lymphopénie</term><term>Pneumopathie infectieuse</term><term>Thrombopénie</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Facteur de croissance épidermique</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hyperleucocytose</term><term>Lymphopénie</term><term>Pneumopathie infectieuse</term><term>Thrombopénie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Kinetics</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Viral Load</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Cinétique</term><term>Excrétion virale</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Infections à coronavirus</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Despite the ongoing spread of MERS, there is limited knowledge of the factors affecting its severity and outcomes. We analyzed clinical data and specimens from fourteen MERS patients treated in a hospital who collectively represent a wide spectrum of disease severity, ranging from mild febrile illness to fatal pneumonia, and classified the patients into four groups based on severity and mortality. Comparative and kinetic analyses revealed that high viral loads, weak antibody responses, and lymphopenia accompanying thrombocytopenia were associated with disease mortality, whereas persistent and gradual increases in lymphocyte responses might be required for effective immunity against MERS-CoV infection. Leukocytosis, primarily due to increased neutrophils and monocytes, was generally observed in more severe and fatal cases. The blood levels of cytokines such as IL-10, IL-15, TGF-β, and EGF were either positively or negatively correlated with disease mortality. Robust induction of various chemokines with differential kinetics was more prominent in patients that recovered from pneumonia than in patients with mild febrile illness or deceased patients. The correlation of the virological and immunological responses with disease severity and mortality, as well as their responses to current antiviral therapy, may have prognostic significance during the early phase of MERS.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/srep25359) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Butler, D" uniqKey="Butler D">D Butler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feikin, Dr" uniqKey="Feikin D">DR Feikin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name></author><author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Stephens, Gm" uniqKey="Stephens G">GM Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Js" uniqKey="Yang J">JS Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spanakis, N" uniqKey="Spanakis N">N Spanakis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, Ec" uniqKey="Hung E">EC Hung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Kk" uniqKey="Lau K">KK Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rochman, Y" uniqKey="Rochman Y">Y Rochman</name></author><author><name sortKey="Spolski, R" uniqKey="Spolski R">R Spolski</name></author><author><name sortKey="Leonard, Wj" uniqKey="Leonard W">WJ Leonard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aloui, C" uniqKey="Aloui C">C Aloui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, K" uniqKey="Jung K">K Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Lambertz, Am" uniqKey="Lambertz A">AM Lambertz</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faure, E" uniqKey="Faure E">E Faure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muro, S" uniqKey="Muro S">S Muro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yadava, K" uniqKey="Yadava K">K Yadava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Totura, Al" uniqKey="Totura A">AL Totura</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cazac, Bb" uniqKey="Cazac B">BB Cazac</name></author><author><name sortKey="Roes, J" uniqKey="Roes J">J Roes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moldoveanu, B" uniqKey="Moldoveanu B">B Moldoveanu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, K" uniqKey="Gilbert K">K Gilbert</name></author><author><name sortKey="Fine, Mj" uniqKey="Fine M">MJ Fine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pas, Sd" uniqKey="Pas S">SD Pas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willis, Vc" uniqKey="Willis V">VC Willis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><noCountry><name sortKey="Aigerim, Abdimadiyeva" sort="Aigerim, Abdimadiyeva" uniqKey="Aigerim A" first="Abdimadiyeva" last="Aigerim">Abdimadiyeva Aigerim</name><name sortKey="Cho, Nam Hyuk" sort="Cho, Nam Hyuk" uniqKey="Cho N" first="Nam-Hyuk" last="Cho">Nam-Hyuk Cho</name><name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name><name sortKey="Choi, Myung Sik" sort="Choi, Myung Sik" uniqKey="Choi M" first="Myung-Sik" last="Choi">Myung-Sik Choi</name><name sortKey="Ha, Na Young" sort="Ha, Na Young" uniqKey="Ha N" first="Na-Young" last="Ha">Na-Young Ha</name><name sortKey="Inn, Kyung Soo" sort="Inn, Kyung Soo" uniqKey="Inn K" first="Kyung-Soo" last="Inn">Kyung-Soo Inn</name><name sortKey="Kim, Yuri" sort="Kim, Yuri" uniqKey="Kim Y" first="Yuri" last="Kim">Yuri Kim</name><name sortKey="Min, Chan Ki" sort="Min, Chan Ki" uniqKey="Min C" first="Chan-Ki" last="Min">Chan-Ki Min</name><name sortKey="Shin, Hyun Mu" sort="Shin, Hyun Mu" uniqKey="Shin H" first="Hyun Mu" last="Shin">Hyun Mu Shin</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Cheon, Shinhye" sort="Cheon, Shinhye" uniqKey="Cheon S" first="Shinhye" last="Cheon">Shinhye Cheon</name></noRegion><name sortKey="Kim, Jin Hwan" sort="Kim, Jin Hwan" uniqKey="Kim J" first="Jin-Hwan" last="Kim">Jin-Hwan Kim</name><name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name><name sortKey="Moon, Jae Young" sort="Moon, Jae Young" uniqKey="Moon J" first="Jae Young" last="Moon">Jae Young Moon</name><name sortKey="Sohn, Kyung Mok" sort="Sohn, Kyung Mok" uniqKey="Sohn K" first="Kyung Mok" last="Sohn">Kyung Mok Sohn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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